GETTING MY PKRRATING TO WORK

The activated enzyme then phosphorylates its main substrate, the translational initiation issue eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to some conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to various stimuli12, triggering the integrated strain resp